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Immunology

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Biological and Medical Sciences > Classification by Discipline > Immunology


Branch: Sci-Wiki
Type: General Knowledge
Intention: For Publication
Read/Write Permissions: Open Access
Authors :
19.09.2011 - Christopher Dyer  -  Sci-Mate   
30.01.2011 - John Stewart   
24.03.2009 - Chris Parish  -  ANU   


Immunology is the study of how living systems regulate their interactions with foreign and non-foreign bodies called antigens.

The study of immunology draws heavily upon the major disciplines of Cell Biology and Molecular Biology.

This article is in progress- researchers in this field are invited to contribute, regardless of how long or short the contribution is.

Contents

[edit] Historical Background

[edit] Immune Cells

The major cell types of the immune system include: T Lymphocytes or T Cells; B Cells; Granulocytes; ...

[edit] Cell Lineage

Immune cells within the Blood and lymphatic system develop from a single type of haematopoetic stem cell through a process known as Haematopoiesis.

[edit] Clonal Expansion

... The number of times a cell population goes through division can be measured through CFSE Labelling of cells prior to stimulation, and subsequent FACs analysis.

[edit] Inflammation

Inflammation describes a process in which various cells of the immune system are recruited to a local site of tissue damage or infection following the release of DAMPs.  Key cells involved in inflammation include: Neutrophils.

[edit] Immunity

Where an immune system is capable of resisting the pathological effects of infection, the individual is considered immune to the disease, or to have established immunity. This situation can be achieved through immunization.

[edit] Immune Regulation

The regulation of the immune system refers to the activation and de-activation of specific groups of cells in response to various forms of stimulation. The challenge for regulation is to balance the immune systems goal to rapidly eradicate all threats with the sensible need to avoid 'over-reactions' leading to allergic and autoimmune responses. Our understanding of how this balance is maintained allows us to further explore ways to prevent diseases resulting from inappropriate immune responses.

Following transplantation, clinicians attempt to suppress the host's natural immune response to the implantation of foreign tissue.

[edit] Danger Signals

...

The immune system's response to cell death (see,  Immunology of Cell Death) depends heavily on the release of co-stimulatory molecules called Damage Associated Molecular Patterns.

[edit] NOTE

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