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From Sci-Mate WikiBiological and Medical Sciences > Classification by Discipline > Cell Biology
Type: General Knowledge
Intention: For Publication
Read/Write Permissions: Open Access
09.12.2009 - Christopher Dyer - Sci-Mate
Cell biology is the study of living cells, with particular respect to their internal components and structure, and their interactions with other cells and their environment (as visualized by Biovisions, Harvard).
 Stem Cells
Reim and Wischhusen (2009), have demonstrated selective survival of CD44high/CD24low/HER2low breast cancer stem cells under immunoselection with trastuzumab and NK cells.
 Cell Death
The two known pathways via which cells undergo death have been classified as Programmed Cell Death and Necrosis. The best characterised form of Programmed Cell Death, Apoptosis, involves a relatively well-ordered and regulated process of cell destruction. In such cases, a cascade of molecular events causes the breakdown and compartmentalising of cellular components for eventual phagocytosis. Programmed Cell Death is critically regulated during embryonic development; the maintenance of homeostasis; and in the regulation of immune responses. At the other extreme, Necrosis describes a more violent or chaotic expulsion of cellular contents and ablation of cellular integrity resulting from physical injury/damage of cells.
The questions- if, how, and why cells die- are relevant to the immune system as it seeks to prevent uncontrolled cell death resulting from infection or mutation (see Immunology of Cell Death).
 Cell Culture
Reim, F., Dombrowski, Y., Ritter, C., Buttmann, M., Häusler, S., Ossadnik, M., Krockenberger, M., Beier, D., Beier, C., Dietl, J., Becker, J., Hönig, A., and Wischhusen, J. (2009). Selective survival of CD44high/CD24low/HER2low breast cancer stem cells under immunoselection with trastuzumab and NK cells. Cancer Res. 2009 69: 8058-8066.
Any researcher with sufficient knowledge to improve this article is invited to edit it.